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Data released on August 27, 2015

Supporting data for "Addressing health disparities in Hispanic breast cancer: Accurate and inexpensive sequencing of BRCA1 and BRCA2".

Boland, J; Dean, M; Garland, L; Im, K, M; Mitchell, J; Perez, M; Rodriguez-Herrera, M; Yeager, M; Jones, K; Roberson, D; Lee, H, J; Eggebeen, R; Sawitzke, J; Bass, S; Zhang, X; Hollis, C; Robles, V; Barajas, C; Rath, E; Arentz, C; Figueroa, J, A; Nguyen, D, D; Nahleh, Z (2015): Supporting data for "Addressing health disparities in Hispanic breast cancer: Accurate and inexpensive sequencing of BRCA1 and BRCA2". GigaScience Database. http://dx.doi.org/10.5524/100154 RIS BibTeX Text

Germline mutations in the BRCA1 and BRCA2 genes account for 20 to 25% of inherited breast cancer and about 10% of all breast cancer cases. Detection of BRCA mutation carriers can lead to therapeutic interventions such as mastectomy, oophorectomy, hormonal prevention therapy, improved screening, and targeted therapies such as PARP-inhibition. We estimate that African Americans and Hispanics are 4 to 5 times less likely to receive BRCA screening, despite having similar mutation frequencies as non-Jewish Caucasians and these populations have higher breast cancer mortality. To begin addressing this health disparity, we initiated a nationwide trial of BRCA testing of Latinas with breast cancer. Patients were recruited through community organizations, clinics, public events and through the mail and internet. Subjects completed the consent process and questionnaire, and provided a saliva sample by mail or in person. DNA from 120 subjects was used to sequence the entire BRCA1 and BRCA2 coding regions and splice sites, and validation of pathogenic mutations with a total material cost of $85/subject. Subjects ranged in age from 23-81 years (mean age of 51 years), 6% had bilateral disease, 57% were ER/PR+, 23% HER2+, and 17% had triple-negative disease.

Contact Submitter

Related manuscripts:

doi:10.1186/s13742-015-0088-z

Additional information:

https://clinicaltrials.gov/show/NCT01251900

Genomic

http://gigadb.org/images/data/cropped/100154.jpg

Samples: Table Settings

Columns:

Common Name
Scienfic Name
Sample Attributes
Taxonomic ID
Genbank Name

Sample IDTaxonomic IDCommon NameGenbank NameScientific NameSample Attributes
DL00997899606HumanhumanHomo sapiens Health or disease status of specific host at time of collection:Affected, breast cancer
Sex:female (EFO:0001265)
DL00997909606HumanhumanHomo sapiens Health or disease status of specific host at time of collection:Affected, breast cancer
Sex:female (EFO:0001265)
DL00997919606HumanhumanHomo sapiens Health or disease status of specific host at time of collection:Affected, breast cancer
Sex:female (EFO:0001265)
DL00997929606HumanhumanHomo sapiens Health or disease status of specific host at time of collection:Affected, breast cancer
Sex:female (EFO:0001265)
DL00997939606HumanhumanHomo sapiens Health or disease status of specific host at time of collection:Affected, breast cancer
Sex:female (EFO:0001265)
DL00997949606HumanhumanHomo sapiens Health or disease status of specific host at time of collection:Affected, breast cancer
Sex:female (EFO:0001265)
DL00997959606HumanhumanHomo sapiens Health or disease status of specific host at time of collection:Affected, breast cancer
Sex:female (EFO:0001265)
DL00997969606HumanhumanHomo sapiens Health or disease status of specific host at time of collection:Affected, breast cancer
Sex:female (EFO:0001265)
DL00997979606HumanhumanHomo sapiens Health or disease status of specific host at time of collection:Affected, breast cancer
Sex:female (EFO:0001265)
DL00997989606HumanhumanHomo sapiens Health or disease status of specific host at time of collection:Affected, breast cancer
Sex:female (EFO:0001265)
Displaying 1-10 of 134 Sample(s).

Files: (FTP site) Table Settings

Columns:

File Description
Sample ID
File Type
File Format
Size
Release Date
Download Link
File Attributes

File NameSample IDFile TypeFile FormatSizeRelease Date 
OtherEXCEL190.3 KB2015-08-04
OtherEXCEL68.14 KB2015-08-04
OtherEXCEL130.5 KB2015-08-04
DirectoryUNKNOWN1.77 GB2015-08-04
DirectoryUNKNOWN2.79 GB2015-08-04
DirectoryUNKNOWN2.23 GB2015-08-04
DirectoryUNKNOWN77.33 KB2015-08-04
DirectoryUNKNOWN237.22 KB2015-08-04
DirectoryUNKNOWN46.65 KB2015-08-04
DirectoryUNKNOWN488.56 KB2015-08-04
Displaying 1-10 of 17 File(s).

History:

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