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Data released on January 25, 2017

Data and analysis of diet-induced and obesity-associated alterations of gut microbiota of 129S6/Sv and C57BL/6J mice

Xiao, L; Sonne, S, B; Feng, Q; Chen, N; Xia, Z; Li, X; Fang, Z; Zhang, D; Fjære, E; Midtbø, L, K; Derrien, M; Hugenholtz, F; Li, J; Zhang, J; Liu, C; Hao, Q; Vogel, U, B; Mortensen, A; UR Kleerebezem, M, W; Licht, T, R; Li, Y; Arumugam, M; Wang, J; Madsen, L; Kristiansen, K (2017): Data and analysis of diet-induced and obesity-associated alterations of gut microbiota of 129S6/Sv and C57BL/6J mice GigaScience Database. http://dx.doi.org/10.5524/100271 RIS BibTeX Text

It is well known that the microbiota of high fat (HF) diet-induced obese mice differs from that of lean mice, but to what extent this difference reflects the obese state or the diet is unclear. To dissociate changes in the gut microbiota associated with high HF feeding from those associated with obesity, we took advantage of the different susceptibility of C57BL/6JBomTac (BL6) and 129S6/SvEvTac (Sv129) mice to diet-induced obesity and of their different responses to inhibition of cyclooxygenase (COX) activity, where inhibition of COX activity in BL6 mice prevents HF diet-induced obesity, but in Sv129 mice accentuates obesity.
Using HiSeq-based whole genome sequencing we identified taxonomic and functional differences in the gut microbiota of the two mouse strains fed regular low fat or HF diets with or without supplementation with the COX-inhibitor, indomethacin.
Here we present the sequence assemblies and annotations for those 54 samples, together with the gene catalogue and relevative abundance levels of both genes and OTUs. It is hoped these data can be used for comparison in future studies of a similar design.

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Accessions (data included in GigaDB):

ENA: ERP011540

Metagenomic

http://gigadb.org/images/uploads/image_upload/Images_181.png

Funding:

  • Funding body - Danish National Research Foundation
  • Funding body - Carlsbergfondet
  • Funding body - National Institute Of Nutrition And Seafood Research
  • Funding body - Danish Strategic Research Council
  • Award ID - 11-116163
  • Funding body - Shenzhen Municipal Government of China
  • Location - China
  • Award ID - CXZZ20150330171521403
  • Funding body - Shenzhen Municipal Government of China
  • Location - China
  • Award ID - JCYJ20140418095735538

Samples: Table Settings

Columns:

Common Name
Scienfic Name
Sample Attributes
Taxonomic ID
Genbank Name

Sample IDTaxonomic IDCommon NameGenbank NameScientific NameSample Attributes
indo_1410661mouse gut metagenome Alternative accession-SRA_sample:ERS811228
Body product:feces
Environment (feature):anthropogenic environment [E...
...
+
indo_10410661mouse gut metagenome Alternative accession-SRA_sample:ERS811237
Body product:feces
Environment (feature):anthropogenic environment [E...
...
+
indo_11410661mouse gut metagenome Alternative accession-SRA_sample:ERS811238
Body product:feces
Environment (feature):anthropogenic environment [E...
...
+
indo_12410661mouse gut metagenome Alternative accession-SRA_sample:ERS811239
Body product:feces
Environment (feature):anthropogenic environment [E...
...
+
indo_13410661mouse gut metagenome Alternative accession-SRA_sample:ERS811240
Body product:feces
Environment (feature):anthropogenic environment [E...
...
+
indo_14410661mouse gut metagenome Alternative accession-SRA_sample:ERS811241
Body product:feces
Environment (feature):anthropogenic environment [E...
...
+
indo_15410661mouse gut metagenome Alternative accession-SRA_sample:ERS811242
Body product:feces
Environment (feature):anthropogenic environment [E...
...
+
indo_16410661mouse gut metagenome Alternative accession-SRA_sample:ERS811243
Body product:feces
Environment (feature):anthropogenic environment [E...
...
+
indo_17410661mouse gut metagenome Alternative accession-SRA_sample:ERS811244
Body product:feces
Environment (feature):anthropogenic environment [E...
...
+
indo_18410661mouse gut metagenome Alternative accession-SRA_sample:ERS811245
Body product:feces
Environment (feature):anthropogenic environment [E...
...
+
Displaying 1-10 of 54 Sample(s).

Files: (FTP site) Table Settings

Columns:

File Description
Sample ID
File Type
File Format
Size
Release Date
Download Link
File Attributes

File NameSample IDFile TypeFile FormatSizeRelease Date 
indo_10Sequence assemblyFASTA25.14 MB2017-01-10
indo_11Sequence assemblyFASTA35.91 MB2017-01-10
indo_12Sequence assemblyFASTA32.93 MB2017-01-10
indo_13Sequence assemblyFASTA24.24 MB2017-01-10
indo_14Sequence assemblyFASTA32.03 MB2017-01-10
indo_15Sequence assemblyFASTA37.56 MB2017-01-10
indo_16Sequence assemblyFASTA31.05 MB2017-01-10
indo_17Sequence assemblyFASTA37.8 MB2017-01-10
indo_18Sequence assemblyFASTA40.91 MB2017-01-10
indo_19Sequence assemblyFASTA24.34 MB2017-01-10
Displaying 1-10 of 71 File(s).

History:

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